LISRAYA is a once-daily pill proven to help adults with dermatomyositis
What makes LISRAYA unique?
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There’s now an FDA-approved once daily pill for adults with
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dermatomyositis.
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Here’s how it works.
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Dermatomyositis, or DM, is an autoimmune disease,
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meaning the immune system attacks healthy muscle and skin instead of protecting
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it. This can cause debilitating muscle weakness that makes
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everyday activities a real challenge, and painful itchy
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skin rashes.
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DM is caused by an overactive immune system.
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Think of certain switches in your body’s immune system as being stuck in the on
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position, leading to the constant inflammation that causes symptoms.
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LISRAYA, a once-daily pill has a unique way of
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working. Unlike other DM treatments that suppress your immune system
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generally, LISRAYA turns off specific inflammatory switches
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stuck in the on position. By flipping these switches,
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LISRAYA helps interrupt inflammatory signals driving DM,
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reducing the immune system’s attack on healthy muscle and skin.
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In a clinical study, DM patients taking LISRAYA experienced
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improvements including in their skin symptoms, muscle strength,
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and daily function as early as four weeks after starting treatment,
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and they continued getting better through the end of the 52-week
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study. LISRAYA also helped patients significantly reduce their
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reliance on steroids while still improving their
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disease. LISRAYA can lower your ability to fight
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infections. Before treatment, test for TB and do blood
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work. Serious infections, cancers, heart attack,
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stroke, blood clots, and death have occurred.
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Tell your doctor if you’ve had these events, infection, Hep B or C,
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smoked, are pregnant, or planning.
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Now you understand how LISRAYA can help.
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So talk with your doctor to learn if LISRAYA could be right for you.
Key benefits of LISRAYA
LISRAYA blocks specific inflammatory signals that drive DM, so you can:
The First Targeted Treatment
Increase your muscle strength
Improve your skin symptoms
Rely less on steroidsLISRAYA delivers improvements as early as 4 weeks after starting treatment.
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My name is Dr. Michael Allen. I’m a board-certified rheumatologist and assistant
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professor of medicine at Albany Medical College.
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I have a special interest in systemic autoimmune conditions, particularly
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dermatomyositis and other rheumatic diseases that can affect the muscles, joints,
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and lungs. For a long time, we as physicians simply haven’t had targeted treatments
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to offer patients with this debilitating disease.
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Most of the medications we traditionally used in dermatomyositis, or DM, including
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oral steroids like prednisone, older immunosuppressants like methotrexate,
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mycophenolate, or azathioprine, have remained our go-to in dermatomyositis because
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we didn’t have any other options. These drugs work generally by blocking the immune
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system, and most of them have limited evidence from randomized control trials in
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DM. That’s why I’m excited about a newly approved oral medication called LISRAYA for
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adults living with dermatomyositis.
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LISRAYA was specifically developed and studied in patients with dermatomyositis.
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It’s a once-daily pill designed to target inflammatory signals in the body that are
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believed to play a central role in driving disease rather than broadly suppressing
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the immune system in the way that many older therapies do.
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Importantly, LISRAYA was evaluated in a dedicated clinical trial that only enrolled
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patients with dermatomyositis rather than a mixed group of patients with different
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forms of myositis or unrelated autoimmune diseases.
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In fact, the 52-week VALOR study, which led to the approval of LISRAYA in
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dermatomyositis, was the largest placebo-controlled clinical trial ever conducted
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specifically in dermatomyositis.
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All that is to say, for patients and families navigating the daily challenges of
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dermatomyositis, including ongoing symptoms and the unpredictability of the disease
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itself, LISRAYA may represent a proven, new, and targeted treatment option.
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If you’d like to learn more about whether LISRAYA might be right for you, I’d
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encourage you to bring it up with your doctor.
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LISRAYA can lower your ability to fight infections.
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Before treatment, test for TB and do blood work.
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Serious infections, cancers, heart attack, stroke, blood clots, and death have
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occurred. Tell your doctor if you’ve had these events, infection, Hep B or C,
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smoked, are pregnant, or planning. Don’t take if allergic or have an infection.
The study results behind the benefits
LISRAYA targets root causes of dermatomyositis
Toggle the button to see how LISRAYA works on an immune system with DM
with Dermatomyositis
with LISRAYA
Immune System with Dermatomyositis
In DM, certain parts of your body’s immune system get stuck in the “on” position. They become overactive, leading to unwanted inflammation that targets your skin and muscle cells, causing common DM symptoms.
Immune System with LISRAYA
LISRAYA works differently from other DM treatments. It turns off specific inflammatory switches that are stuck in the “on” position rather than suppressing the immune system generally.
What people are saying about LISRAYA
Hear from a person living with DM and a doctor about their experiences with LISRAYA.
With LISRAYA, I was able to regain my sense of independence and reintegrate into my typical lifestyle and activities of daily living.
Candice
Diagnosed with dermatomyositis in 2017
See More Patient Stories
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I am Candice. I live in Park Forest, Illinois, which is a suburb that’s 20
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miles south of Chicago. Born and raised in Chicago all my life.
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I’m 46 years old. My symptoms first began with a simple rash on my
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thigh burns, really simple, didn’t think much about it, and I just began to get
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worse and worse, going down and down and down, to the point where I had a complete
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and total shutdown. Being on multiple prescriptions, trying to manage the
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symptoms was extremely frustrating because nothing worked.
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When I tell you nothing worked, my skin was on fire. It was red.
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85% of my body was covered in red, angry rashes from my face
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all the way down to my calves, completely covered.
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I was in a clinical trial for a DM treatment.
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When I was in the trial, I began to notice a subtle change.
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It didn’t come all of a sudden, but gradually.
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I just began to notice that my arms started clearing up, my thighs began to
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clear up. My whole entire back once was like sandpaper.
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It started to resume its texture and smoothness.
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My partner, he began to notice, like, “No, I think it’s lightening up a little
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bit.” And a lot of times, I was sensitive to the touch, so if somebody touched me,
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I would immediately jump, and he was noticing that I was just more relaxed and
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could just take physical touch a lot better.
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When
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I stayed diligent taking the trial drug, and I began to notice significant change,
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it was literally like a weight was being lifted off of me. Literally.
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It was almost like if you’ve been in a bad dream,
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and you wake up and you realize and like, “Oh, it was just a dream.
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I’m okay.” So I began to come back to a sense of peace and feeling like, you know
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what? This is going to be okay. This drug is working, and it’s going to be okay.
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So one piece that have improved for sure with the trial drug was no more cuts.
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No more sores, no more cuts. I had sores all on my neck, sores on my
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eyelids, so the sores have completely been alleviated. Completely.
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And that’s a huge blessing because that was really tough to deal with.
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After getting on the trial drug, I slowly but surely started to realize that my
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strength was coming back and that I just didn’t need as much assistance with the
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activities of my daily life. It felt amazing to be less dependent on
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others for my basic needs because as much as they love me, I am a
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strong woman who wants to be independent and take care of myself.
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So it felt amazing to regain my sense of strength and sense of self back.
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I’m coming out on the other side, and after being on this trial drug, it has given
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me a renewed sense that there is life after.
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And even though I’ve been in a ring boxing DM, that I’m
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not defeated. I’m not defeated, and there’s life after.
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And even though life looks a little different for me now,
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I have hope. I have hope that it’s going to get better. I really do believe that.
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LISRAYA can lower your ability to fight infections.
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Before treatment, test for TB and do blood work.
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Serious infections, cancers, heart attack, stroke, blood clots, and death have
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00:03:53 –> 00:03:58
occurred. Tell your doctor if you’ve had these events, infection, Hep B or C,
48
00:03:58 –> 00:04:02
smoked, are pregnant or planning. Don’t take if allergic or have an infection.
Learn more about LISRAYA
