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LISRAYA, the first once-daily pill proven to help adults with dermatomyositis (DM)

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LISRAYA is an FDA-approved treatment that helps you:

Increase your muscle strength
Rely less on steroids
Improve your skin symptoms
Do more of the daily activities you love

Proven to deliver results for adults with DM

Patients taking LISRAYA saw significant improvement in their dermatomyositis in a 52-week study, the largest ever conducted in DM. Patients experienced benefits across skin disease, muscle strength, and daily function, with improvements starting as early as four weeks. Most were also able to completely stop taking steroids or take only a very low dose.

See the Study Results
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You may be eligible to pay as little as $0* per month for LISRAYA

*The My Compass Support Copay Savings Program is subject to the terms and conditions found here.

My Compass Support is here 
to help you navigate treatment

When you enroll in My Compass Support, you’ll get ongoing, personalized assistance from a dedicated Patient Access Liaison (PAL) as you start and continue LISRAYA.

My Compass Support

What you get with 
My Compass Support

Direct Communication
Cost Assistance
Insurance Approval Help
Specialty Pharmacy Coordination
Personalized Support
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Learn how My Compass Support can help you navigate treatment with LISRAYA

Hear from real people taking LISRAYA

Individual results may vary

Tamara, a real patient taking LISRAYA for dermatomyositis, sitting outdoors with her dog

I went from somebody who could barely get off a couch to going back to work and being social, being able to do things again.

Tamara
Diagnosed with dermatomyositis in 2022
See Story
Mary, a real patient taking LISRAYA for dermatomyositis, smiling outdoors

I feel like I’m getting back to my normal self.

Mary
Diagnosed with dermatomyositis in 2022
See Story
Veronica, a real patient taking LISRAYA for dermatomyositis, smiling while seated outdoors

You don’t realize how important the little things are until you cannot do them. And when you get them back, you appreciate them more.

Veronica
Diagnosed with dermatomyositis in 2021
See Story
Glennis, a real patient taking LISRAYA for dermatomyositis, standing outdoors by a barn

With LISRAYA, I could get dressed by myself, play with the grandkids, and get in and out of vehicles.

Glennis
Diagnosed with dermatomyositis in 2021
See Story
Candice, a real patient taking LISRAYA for dermatomyositis, smiling indoors with her arms folded

I was able to regain my sense of independence and reintegrate into my typical lifestyle and activities of daily living.

Candice
Diagnosed with dermatomyositis in 2017
See Story
Kristen, a real patient taking LISRAYA for dermatomyositis, smiling with her arms folded

I knew LISRAYA was working when the rash on my face, chest, and hands completely went away.

Kristin
Diagnosed with dermatomyositis in 2002
See Story
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Indication

LISRAYA (brepocitinib) is used for the treatment of adults with dermatomyositis (DM).

Limitations of Use
LISRAYA should not be used in combination with other JAK inhibitors, other TYK2 inhibitors, or biologic DMARDs.

Important Safety Information

WARNING: SERIOUS INFECTIONS, MORTALITY, MALIGNANCY, MAJOR ADVERSE CARDIOVASCULAR EVENTS (MACE), and THROMBOSIS

USE
LISRAYA (brepocitinib) is used for the treatment of adults with dermatomyositis (DM).

Limitations of Use
LISRAYA should not be used in combination with other JAK inhibitors, other TYK2 inhibitors, or biologic DMARDs.

LISRAYA can cause serious side effects, including:
Serious infections. LISRAYA can lower your ability to fight infections. Serious infections have happened while taking LISRAYA, including active tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections. Your healthcare provider (HCP) should test you for TB before starting LISRAYA and check you closely for signs and symptoms of TB during treatment with LISRAYA. You should not start taking LISRAYA if you have any kind of infection unless your HCP tells you it is okay. If you get a serious infection, your HCP may stop your treatment until your infection is controlled. You may be at higher risk of developing shingles (herpes zoster).

Increased risk of death in people 50 years of age and older who have at least 1 heart disease risk factor and are taking a medicine in the class of medicines called Janus kinase (JAK) inhibitors. LISRAYA is a JAK inhibitor medicine.

Cancer and immune system problems. LISRAYA may increase your risk of certain cancers. Lymphoma and other cancers, including skin cancers, can happen. Current or past smokers are at higher risk of certain cancers, including lymphoma and lung cancer. Follow your HCP’s advice about having your skin checked for skin cancer during treatment with LISRAYA. Limit the amount of time you spend in sunlight. Wear protective clothing when you are in the sun and use sunscreen.

Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a JAK inhibitor, especially if you are a current or past smoker.

Blood clots. Blood clots in the veins of your legs or lungs and arteries can happen in some people taking LISRAYA. This may be life-threatening and cause death. Blood clots in the veins of the legs and lungs have happened more often in people who are 50 years of age and older with at least 1 heart disease (cardiovascular) risk factor taking a JAK inhibitor.

Allergic Reactions. Symptoms such as rash (hives), trouble breathing, feeling faint or dizzy, or swelling of your lips, tongue, or throat that may mean you are having an allergic reaction have been seen in people taking LISRAYA. Some of these reactions were serious. If any of these symptoms occur during treatment with LISRAYA, stop taking LISRAYA and get emergency medical help right away.

Tears in the stomach or intestines. Some people taking LISRAYA can get tears in their stomach or intestines. This happens most often in people who take nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids. Get medical help right away if you get stomach-area pain, fever, chills, nausea, or vomiting.

Low blood sugar in people with diabetes. If you have diabetes, your healthcare provider may tell you to check your blood sugar (glucose) more often during treatment with LISRAYA. Call your healthcare provider if you have any problems with low blood sugar.

Changes in certain laboratory tests. Your HCP should do blood tests before you start taking LISRAYA and while you take it. Your HCP may stop your LISRAYA treatment for a period of time if needed because of changes in these blood test results.

Before taking LISRAYA, tell your HCP if you:

  • have an infection.
  • are a current or past smoker.
  • have had any type of cancer.
  • have had a heart attack or other heart problems, or stroke.
  • have liver or kidney problems.
  • have unexplained stomach (abdominal) pain, have a history of diverticulitis or ulcers in your stomach or intestines, or are taking NSAIDs.
  • have diabetes.
  • have low red or white blood cell counts.
  • have recently received or are scheduled to receive an immunization (vaccine). People taking LISRAYA should not receive live vaccines.
  • are pregnant or plan to become pregnant. LISRAYA may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. LISRAYA may pass into your breast milk. Do not breastfeed during treatment with LISRAYA and for 3 days after your last dose of LISRAYA. 

Females who are able to become pregnant:

  • Your healthcare provider will check whether or not you are pregnant before you start treatment with LISRAYA.
  • You should use effective birth control (contraception) to avoid becoming pregnant during treatment with LISRAYA and for 3 days after your last dose of LISRAYA.
  • Tell your healthcare provider if you think you are pregnant or become pregnant during treatment with LISRAYA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. LISRAYA and other medicines may affect each other, causing side effects.

Especially tell your healthcare provider if you take medicines that affect your immune system as these medicines may increase your risk of infection. Ask your healthcare provider or pharmacist if you are not sure if you are taking any of these medicines.

The most common side effects of LISRAYA include:

  • common cold, sinus infections, or sore throat (upper respiratory tract infections)
  • headache
  • tired or lack of energy (fatigue)
  • urinary tract infection
  • nausea
  • acne
  • diarrhea
  • falls
  • bronchitis
  • flu (influenza)
  • joint pain (arthralgia)
  • back pain

Please see the Full Prescribing Information, including BOXED WARNING, and Medication Guide.